Behandelcentrum Neuropathische Pijn
Algemeen Wetenschap sodium valproate and glyceryl trinitrate spray in neuropathic pain
| sodium valproate and glyceryl trinitrate spray in neuropathic pain |
|
Creams and sprays are promissing in the treatment of neuropathic pain.
An Indian reserach group starts stateting that combination of drugs with different mechanisms of action helps in achieving synergistic analgesic effect in neuropathic pain. This is also opur experience. They designed a prospective double-blind randomized placebo-controlled study in eighty-seven type 2 diabetics with painful neuropathy of which 83 were given either sodium valproate and GTN spray (group A) or placebo drug and GTN spray (group B) or sodium valproate and placebo spray (group C) or placebo drug and placebo spray (group D). The results: All the three treatment groups experienced significant improvement in pain score in their drug phase of trial (p<0.001/<0.05). The assessment of the magnitude of therapeutic effect of sodium valproate, GTN and their combination gave numbers needed to treat (NNT) of 7, 5 and 4, respectively. The conclusion was that Sodium valproate and GTN are well tolerated and provide significant improvement in pain scores as well as in electrophysiological parameters. [1] This is in line with our own experience with our ORES 1 and 2 cremes, using capsaicine, lidocaine and isosorbide dinitrate. [2] Transdermal applications need more attention and can help patients suffering from neuropathic pain. From the Centre for the study and treatment of neuropathic pain and neuropathy in Soest, the NertherlandsThis site helps patients and treating physicians, neurologists, anesthesiologists and other pain specialists to find the best and most up to date research findings related to neuropathy and neuropathic pain and the treatment thereof. In our centre we are specialised in treating patients suffering from neuropathic pain and neuropathy following an Integrated Medicine concept. Part of our activities are within the field of consultation. We assist pharmaceutical companies in R&D strategies related to finding new drugs to treat neuropathic pain and neuropathy. February 2010, Jan M. Keppel Hesselink, MD, PhD. Referenties[1]: Agrawal RP, Goswami J, Jain S, Kochar DK. | Management of diabetic neuropathy by sodium valproate and glyceryl trinitrate spray: a prospective double-blind randomized placebo-controlled study. | Diabetes Res Clin Pract. | 2009 Mar;83(3):371-8. [2]: Kopsky DJ, Keppel Hesselink JM. | A new combination cream for the treatment of severe neuropathic pain. | J Pain Symptom Manage. | 2010 Feb;39(2):e9-e10. |