Potentiele huidindicaties voor palmitoylethanolamide

Enkele huidaandoeningen waarbij de behandeling van Normast zinvol kan zijn op basis van de pathogenese van deze aandoeningen en in het licht van de werking van palmitoylethanolamide (Normast) op de mestcel. Huidaandoeningen Chronische onbegrepen huidontstekingen [1] [2] [3] [4] [5] Chronische onbegrepen jeuk [6] [7] Atopische en contactdermatitis [8] [9] [10] [11] Psoriasis [12] [13] [14] Referenties [1]: De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S, Iuvone T. | Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. | Mol Pain. | 2011 Jan 10;7:3. [2]: Petrosino S, Iuvone T, Di Marzo V. | N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities. | Biochimie. | 2010 Jun;92(6):724-7. Epub 2010 Jan 21. [3]: Endocannabinoid Research Group, De Filippis D, D'Amico A, Cipriano M, Petrosino S, Orlando P, Di Marzo V, Iuvone T. | Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats. | Pharmacol Res. | 2010 Apr;61(4):321-8. Epub 2009 Nov 17. [4]: Hoareau L, Buyse M, Festy F, Ravanan P, Gonthier MP, Matias I, Petrosino S, Tallet F, d'Hellencourt CL, Cesari M, Di Marzo V, Roche R. | Anti-inflammatory effect of palmitoylethanolamide on human adipocytes. | Obesity (Silver Spring). | 2009 Mar;17(3):431-8. Epub 2009 Jan 8. [5]: De Filippis D, D'Amico A, Cinelli MP, Esposito G, Di Marzo V, Iuvone T. | Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. | J Cell Mol Med. | 2009 Jun;13(6):1086-95. Epub 2008 Apr 18. [6]: Machelska H. | Dual peripheral actions of immune cells in neuropathic pain. | Arch Immunol Ther Exp (Warsz). | 2011 Feb;59(1):11-24. Epub 2011 Jan 14. [7]: Ständer S, Raap U, Weisshaar E, Schmelz M, Mettang T, Handwerker H, Luger TA. | Pathogenesis of pruritus. | J Dtsch Dermatol Ges. | 2011 Jun;9(6):456-463. doi: 10.1111/j.1610-0387.2011.07585.x. Epub 2011 Jan 5. [8]: Järvikallio A, Naukkarinen A, Harvima IT, Aalto ML, Horsmanheimo M. | Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema. | Br J Dermatol. | 1997 Jun;136(6):871-7. [9]: Eberlein B, Eicke C, Reinhardt HW, Ring J. | Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). | J Eur Acad Dermatol Venereol. | 2008 Jan;22(1):73-82. [10]: Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D'Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V. | Protective role of palmitoylethanolamide in contact allergic dermatitis. | Allergy. | 2010 Jun 1;65(6):698-711. Epub 2009 Nov 11. [11]: Kircik L. | A nonsteroidal lamellar matrix cream containing palmitoylethanolamide for the treatment of atopic dermatitis. | J Drugs Dermatol. | 2010 Apr;9(4):334-8. [12]: Harvima IT, Nilsson G, Naukkarinen A. | Role of mast cells and sensory nerves in skin inflammation. | G Ital Dermatol Venereol. | 2010 Apr;145(2):195-204. [13]: Kneilling M, Röcken M. | Mast cells: novel clinical perspectives from recent insights. | Exp Dermatol. | 2009 May;18(5):488-96. [14]: Harvima IT, Nilsson G, Suttle MM, Naukkarinen A. | Is there a role for mast cells in psoriasis? | Arch Dermatol Res. | 2008 Oct;300(9):461-78. Epub 2008 Aug 22.