Potentiele gastrointestinale indicaties voor palmitoylethanolamide

Binnen de gastrointestinale indicaties zijn er een aantal waarvan de symptomatologie en de pathogenese verwijzen naar ontsporingen van de fysiologie van de mestcel. Dat zijn dus potentiele indicaties voor palmitoylethanolamide. Intestinale ontstekingen en pijnsyndromen [1] [2] Colitis ulcerosa [3] [4] [5] Morbus Crohn [6] [7] Prikkelbaar darmsyndroom [8] [9] Proctitis [10][11] [10] Chronische onbegrepen buikpijn [13] [9] Referenties [1]: De Filippis D, D'Amico A, Iuvone T. | Cannabinomimetic control of mast cell mediator release: new perspective in chronic inflammation. | J Neuroendocrinol. | 2008 May;20 Suppl 1:20-5. [2]: Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, Asadi S, Vasiadi M, Weng Z, Miniati A, Kalogeromitros D. | Mast cells and inflammation. | Biochim Biophys Acta. | 2010 Dec 23. [Epub ahead of print] [3]: Peterson CG, Sangfelt P, Wagner M, Hansson T, Lettesjö H, Carlson M. | Fecal levels of leukocyte markers reflect disease activity in patients with ulcerative colitis. | Scand J Clin Lab Invest. | 2007;67(8):810-20. [4]: Rognum TO, Brandtzaeg P. | IgE-positive cells in human intestinal mucosa are mainly mast cells. | Int Arch Allergy Appl Immunol. | 1989;89(2-3):256-60. [5]: O'Sullivan SE, Kendall DA. | Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease. | Immunobiology. | 2010 Aug;215(8):611-6. Epub 2009 Oct 14. [6]: Lakhan SE, Kirchgessner A. | Neuroinflammation in inflammatory bowel disease. | J Neuroinflammation. | 2010 Jul 8;7:37. [7]: Kraneveld AD, Rijnierse A, Nijkamp FP, Garssen J. | Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome: future therapeutic targets. | Eur J Pharmacol. | 2008 May 13;585(2-3):361-74. Epub 2008 Mar 18. [8]: Foley S, Garsed K, Singh G, Duroudier NP, Swan C, Hall IP, Zaitoun A, Bennett A, Marsden C, Holmes G, Walls A, Spiller RC. | Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation. | Gastroenterology. | 2011 May;140(5):1434-43.e1. Epub 2011 Mar 23. [9]: Chang JY, Talley NJ. | An update on irritable bowel syndrome: from diagnosis to emerging therapies. | Curr Opin Gastroenterol. | 2010 Nov 18. [Epub ahead of print] [10]: Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S, Mor M, Russo R, Maccarrone M, Antonietti F, Duranti A, Tontini A, Cuzzocrea S, Tarzia G, Piomelli D. | Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. | Proc Natl Acad Sci U S A. | 2009 Dec 8;106(49):20966-71. Epub 2009 Nov 19. [11]: Blirando K, Milliat F, Martelly I, Sabourin JC, Benderitter M, François A. | Mast cells are an essential component of human radiation proctitis and contribute to experimental colorectal damage in mice. | Am J Pathol. | 2011 Feb;178(2):640-51. [12]: Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S, Mor M, Russo R, Maccarrone M, Antonietti F, Duranti A, Tontini A, Cuzzocrea S, Tarzia G, Piomelli D. | Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. | Proc Natl Acad Sci U S A. | 2009 Dec 8;106(49):20966-71. Epub 2009 Nov 19. [13]: Taylor TJ, Youssef NN, Shankar R, Kleiner DE, Henderson WA. | The association of mast cells and serotonin in children with chronic abdominal pain of unknown etiology. | BMC Res Notes. | 2010 Oct 21;3:265. [14]: Chang JY, Talley NJ. | An update on irritable bowel syndrome: from diagnosis to emerging therapies. | Curr Opin Gastroenterol. | 2010 Nov 18. [Epub ahead of print]