There are a tremendous number of patients who suffer from chronic pain. Many of these are either not adequately treated, or are treated with compounds and suffer very much from side effects. Most patients we see complain about feeling like a zombie, not able to concentrate anymore or drive cars.
Anno 2012 this is obsolete and patients have the right on side-effect free analgesia.
It is our institutes mission to develop treatment protocols wich will help patients to achieve such side effect low analgesia.
We are developing treatment protocols based on the most modern insights in the neurobiology of pain, and especially also on German (alpha-lipoic acid) and Italian (palmitoylethanolamide) insights, experiences and publications.
Treatment protocols for chronic pains in disorders such as CRPS (Sudeck), diabetic neuropathic pain and post herpetic neuropathic pains have been tested and used extensively within our institute and many patients have found painrelief due to our approach.
This all leads to our institutes mission:
Mission of the institute of neuropathic pain:
To Develop and communicate effective treatment protocols for the treatment of chronic pain free of troublesome side-effects, also for the elderly patients
We achieve our mission via:
- the development of side-effect free topical analgesic creams, based on ketamine, amitriptyline, gabapentine, isosorbide dinitrate, baclofen
- the exploration and further development of natural painkilling compounds such as alpha lipoic acid, palmitoylethanolamide and Boswellia
- information about the use of Cannabis as an analgesic compound
- exploration of compounds focussed on new non-neuronal targets, such as the TOLL-4 receptor (low dose naltrexone, ketamine)
We communicate our findings via:
- Dissimination of our treatment approaches in peer reviewed journals and via the internet, based on the stories of patients (our You Tube channels)
- quick review publications in open source journals
- publications in peer reviewed journals of relevant clinical trials and case reports
- building a patient-friendly and accessable internet site on neuropathic and chronic pain, www.neuropathy.nl
- professional linked in peergroup neuropathy and neuropathic pain
Recent literature form our institute
- Keppel Hesselink, JM (2012)New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide. Open Pain Journal 2012, 5: 12-23
- Keppel Hesselink, JM (2011) Glia as a new target for neuropathic pain, clinical proof of concept for palmitoylethanolamide, a glia-modulator. Anaesthesia, Pain & Intensive Care: http://www.apicareonline.com/?p=881
- Keppel Hesselink JM. Effectiveness of the association micronized N-palmitoylethanolamine (PEA)-transpolydatin in the treatment of chronic pelvic pain. Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):488.
- Kopsky DJ, Keppel Hesselink JM. Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report. Case Report Med. 2011;2011:319750.
- Kopsky DJ, Keppel Hesselink JM. High Doses of Topical Amitriptyline in Neuropathic Pain: Two Cases and Literature Review. Pain Pract. 2011 Jun 16. doi: 10.1111/j.1533-2500.2011.00477.x.
- Liebregts R, Kopsky DJ, Keppel Hesselink JM. Topical Amitriptyline in Post-Traumatic Neuropathic Pain. J Pain Symptom Management Vol. 41, No. 4, April 2011: e6-e8
- Keppel Hesselink JM, Kopsky DJ. Enhancing acupuncture by low dose naltrexone.Acupunct Med. 2011 Mar 17.
- Keppel Hesselink JM, Kopsky DJ. Letter to the editor. Curr Ther Res Clin Exp 2010 71(6): 416-417.
- Keppel Hesselink JM, Kopsky DJ. An integrative approach for the treatment of neuropathic pain. EU J Int Med 2010; 2 (4): 190.
- Kopsky DJ, Keppel Hesselink JM. A quality indicator for CAM interventions: The IOCOB traffic light grading system . EU J Int Med 2010; 2 (4): 242.
- Kopsky DJ, Keppel Hesselink JM Nerve Regeneration in Neuropathic Pain Pain Med 2010 Okt, 11(10):1576.
- Kopsky DJ, Keppel Hesselink JM.A new combination cream for the treatment of severe neuropathic pain. J Pain Symptom Manage. 2010 Feb;39(2):e9-e10.
- Soe SH, Kopsky DJ, Jongen PJ, de Vet HC, Oei-Tan CL. Multiple sclerosis patients with bladder dysfunction have decreased symptoms after electro-acupuncture. Mult Scler. 2009 Nov;15(11):1376-7.
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