The dose of palmitoylethanolamide was twice 600 mg; pregabalin was slowly titrated in a bid dose regime, starting with 150 mg/day, after 10 days to 225 mg/day, after 10 days to 300 mg/day and again after 10 days up to 400 mg/dag.

The therapy with pregabalin and palmitoylethanolamide significantly improved pain, functional disability and sleep in a pre versus post comparison. Important to note was: there were no tolerability issues, and the impression that tolerability of pregabalin improved by adding palmitoylethanolamide. ^[1]

These clinical results, although from an open study, adds to the already existing data supporting efficacy and safety of palmitoylethanolamide. ^{[2] [3] [4] [5][6][7][8] [9][10][11][12][13][14]} 

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