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TRO19622, Olesoxime in painful neuropathy

TRO19622 is the code name for the substance olesoxime currently being studied for painful neuropathy. It is a cholesterol-like substance that is designed to be a treatment of a serious disease, such as amyotrophic lateral sclerosis. Animal studies showed the neuroprotective activity, based on the its mechanism of action within the nerve cell.Trophos SA,is developing therapeutics from discovery to clinical validation for indications with under-served needs in neurology and cardiology.Olesoxime is tested in an ongoing pivotal efficacy study in amyotrophic lateral sclerosis, snd efficacy results are expected in 2011.

It is therefore now in the U.S. tested in painful polyneuropathy by chemotherapy:

Olesoxime targets mitochondrial proteins and its effects are consistent with the mitotoxicity hypothesis for paclitaxel-evoked painful peripheral neuropathy. We conclude that olesoxime may be useful clinically for both the prevention and treatment of paclitaxel-evoked painful peripheral neuropathy. ^[1]

March 2010, Jan M. Keppel Hesselink, MD, PhD

Referenties

[1]: Xiao WH, Zheng FY, Bennett GJ, Bordet T, Pruss RM. | Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. | Pain. | 2009 Dec 15;147(1-3):202-9. Epub 2009 Oct 14.