Instituut voor Neuropathische Pijn

KU-32 in diabetic neuropathy

KU-32 showed promessing effects in a mice model. KU-32 inhibits a specific member of a family of proteins, the socalled molecular chaperones. Diabetic mice were administered KU-32. The compound effectively stopped diabetic polyneuropathy and could even restore the sensory neuron functions of the damaged nerve tissue.  The study was published in September 2010 in the American Society of Neurochemistry’s journal, ASN Neuro. KU-32 in this preclinical study was orally administered once a week and was effective given in this low frequency. It could also be administered in small doses. The drug seems nontoxic and could be absorbed into the blood stream fairly well. September 2010, Jan M. Keppel Hesselink, MD, PhD