Small fibre neuropathic pain is very difficult to treat. By prescribing Normast®, a body own fatty compound modulating neuropathic pain via glia, we succeeded to reduce more than 50% the pain scores within 4 weeks, while the diagnostic neuropathic pain score on the DN4 decreased from 5 to 2!

Small fiber peripheral neuropathy is a type of neuropathy. It is also called a small fiber neuropathy or small fiber sensory (or panful) neuropathy (SFSN) and also C fiber neuropathy. 

Small nerve fibers are the nerve fibers near the skin's surface that carry sensation and pain. They are unmyelinated (meaning they don't have an isolating fatty layer), and conduct slowly. They carry mostly pain and temperature sensation. The other nerves to muscles are usually myelinated, conducting faster. These are in general not affected in small fibre neuropathy. That is why you cannot measure small fibre neuropathy via the usual EMG.

Treatment with palmitoylethanolamide (Normast®) had clear neasurable effects and  the pain decreased significantly. The quality of life increased, and after 2 years this patient could restart working as a executive in his own company... After 4 weeks the pain did not qualify for neuropathic pain anymore on the DN 4 scale...

Normast® is registered as food for medical purposes, and has been evaluated in various clinical trials. No sedative side effects, nor drug interactions have been seen yet. ^[1][2][3][4]

David J Kopsky, MD treating pain specialist and prof. Jan M. Keppel Hesselink, MD, PhD, November 2010 

From the institute of neuropathic pain, Netherlands

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