Instituut voor Neuropathische Pijn
| Angina pain and pain due artrosis treated with Normast |
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Paindue to severe artrosis and pain due to angina pectoris, which did onlypartly respond to two dotter procedures, and 4 anti angina drugs,reacted positive on the treatment with the endocannabinoidpalmitoylethanolamide, Normast, available as foodsupplement in theNetherlands.
Angina pain, pain on the chest. Refractory angina pectoris pain is seen as a variety of neuropathic pain. In our clinic we treat neuropathic pains with amongst others the natural and body-own painkiller Normast. Here a presentation of a patient suffering from refractory angina pain, treated with Normast. This is not the Kounis syndrome, but mast cells must have something tot do with it. Kounis syndrome is the essence of mast cell degranulation and angina pectoris attacks. Angina pectoris attacks in Kounis syndrome are caused by inflammatory mediators from mast cells, released during an allergic insult. Allergic angina can progress to acute myocardial infarction, which is termed ‘allergic myocardial infarction’. [1] Palmitoylethanolamide and a putative new subvariety of angina pectoris: MCMAP, Mast Cell Mediated Angina Pectoris In the pathogenesis of unstable angina pro-inflammatory cytokines also play a role. These cytokines may also be responsible for the activation of other cells, as neutrophils or mast-cells.[2] Mast cells have been described playing a role in the pathogenesis of angina pectoris already since long. [3]Our by chance finding of the anti anginal effect of palmitoylethanolamide might define mast-cell dependent angina pectoris. It provokes us to suggest prescribing palmitoylethanolamide to angina pectoris patients to thus, ex juvantibus, be able to define a subpopulation of angina pectoris patients. We would suggest to classify this variety of angina pectoris as Mast Cell Mediated Angina Pectoris, MCMAP. We are very much looking forward to experiences of other clinicians using palmitoylethanolamide in angina pectoris. Jan M. Keppel Hesselink, MD, PhD, May 2011 |