Sudeckse dystrofie, chronisch regionaal pijnsyndroom (CRPS) is een lastig te behandelen vorm van neuropathische pijn.

In dit filmpje vertelt een patient met CRPS type I over zijn pijn en de duidelijke pijnvermindering met de INP-cremes die we in ons centrum zelf ontwikkeld hebben: amitriptyline 5%, ketamine 10% en DMSO 50% creme's. 

Aanvragen pijnstillende creme's op INP-basis

In ons instituut hebben we een hele serie speciale cremes ontwikkeld om ernstige pijnen te behandelen via de huid, op basis van o.a. ketamine, baclofen en gabapentine. U kan bij ons een consult aanvragen, zodat onze apotheker voor u de creme kan afleveren. De INP-creme's worden vergoed door de ziektekostenverzekeraars. 

Pijnstillende INP-creme's: optimale wijze van behandelen 

David J. Kopsky, arts, November 2010, revisie maart 2012, JMKH

Relevante literatuur over CRPS en behandeling 

de Mos M, Huygen FJ, van derHoeven-Borgman M, Dieleman JP, Ch Stricker BH, Sturkenboom MC. Outcome of the complex regional painsyndrome. Clin J Pain. 2009 Sep;25(7):590-7.

Backonja MM, Irving G, Argoff C. Rational multidrug therapy in the treatmentof neuropathic pain. Curr Pain Headache Rep. 2006 Feb;10(1):34-8.

Gallagher RM. Management of neuropathic pain: translating mechanisticadvances and evidence-based research into clinical practice. Clin J Pain. 2006Jan;22(1 Suppl):S2-8.

Maihöfner C, Seifert F, Markovic K. Complex regional pain syndromes:new pathophysiological concepts and therapies. Eur J Neurol. 2010May;17(5):649-60.

Hsu ES. Practical management of complex regional pain syndrome. Am JTher. 2009 Mar-Apr;16(2):147-54.

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Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. CochraneDatabase Syst Rev. 2007 Oct 17;(4):CD005454.

Lockhart E. Topicalcombination of amitriptyline and ketamine for post herpetic neuralgia. J Pain2004;5:S82.

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Kiefer RT, Rohr P, Ploppa A,Dieterich HJ, Grothusen J, Koffler S, Altemeyer KH, Unertl K, Schwartzman RJ. Efficacyof ketamine in anesthetic dosage for the treatment of refractory complex regionalpain syndrome: an open-label phase II study. Pain Med 2008; 9:1173-1201.

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Ushida T, TaniT, Kanbara T, et al. Analgesiceffects of ketamine ointment in patients with complex regional pain syndrometype 1. Reg Anesth Pain Med 2002;27:524–8.

Coggeshall R, Carlton S. Receptor localization in the mammaliandorsal horn and primary afferent neurons. Brain Res Rev 1997;24:28–66.

Carlton SM, Coggeshall RE. Inflammation-induced changes in peripheralglutamate receptor populations. Brain Res 1999;820:63-70.

Zuurmond WW, Langendijk PN,Bezemer PD, Brink HE, de Lange JJ, van Loenen AC. Treatment of acute reflex sympathetic dystrophywith DMSO 50% in a fatty cream. Acta Anaesthesiol Scand 1996, 40:364-367.