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In this section English articles are published on neuropathy.

CR845 (Difelikefalin), A Kappa Receptors Agonist In Phase III By CARA Therapeutics

CR845: (difelikefalin), a peripheral opioid agonist currently developed by Cara Therapeutics, an analysis.

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SFN Pain Scale: Small Fibre Neuropathic Pain Scale

The SFN scale: a patient rated Small Fibre Neuropathic Pain Scale.

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Phenytoin cream normalizes neural overactivity in skin in neurogenic inflammation

Phenytoin cream is a newly developed cream by the Institute of Neuropathic Pain and protected by 2 patents, filed on December 6th, 2016. The cream contains 5 or 10% phenytoin and here we picture one of the mechanisms of action, via the keratinocyte.

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MicroPEA: an essential component of modern PEA formulations!

MicroPEA is the content of special patented PEA formulations. Only these formulations have a long trackrecord of safety and efficacy.

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Polyneuropathy: an Introduction

Polyneuropathy: all you want to know

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Rheumatism, Bechterew disease, mast cells and palmitoylethanolamide

Bechterew is a rheumatic disorder based on chronic inflammation. Since some years the treatment with the natural painkiller and anti-inflammation compound palmitoylethnanolamide in its new formulations containing micro-PEA gives new hope.

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Prostate, chronic pain and treatment with palmitoylethanolamide

Prostate Pains can be treated with the natural anti-inflammatory compound palmitoylethanolamide (PEA). We prefer PEA formulations containing micro-PEA (m-PEA, um-PEA and PEA-opt) as in Normast, PeaPure and PeaPlex.

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Treat burning and painful vagina with natural substance PEA

Vaginal pain, vaginal burning! This is quite common, more so than we think. Specifically among women older than 45 years of age. Many women don’t speak about it, but they do suffer from it. In case of vaginal pain, pain during intercourse or vaginal burning, it is obvious that the doctor or gynecologist needs to […]

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Amputation pain, phantom limb pain and treatment with palmitoylethanolamide

Post-amputation pain is a serious and difficult to treat pain, also referred to as phantom pain. Phantom pain can occur in the arms, legs, hand and feet after amputation, but also in cases of breast amputation related to cancer. Palmitoylethanolamide (PEA) is a natural and body’s own substance that has a pain relieving and anti-inflammatory […]

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MS spasms and pain treatment with body’s own substance palmitoylethanolamide

Palmitoylethanolamide is a new and promising treatment against pain and inflammation. It’s available as a supplement without prescription. PeaPure is a supplement in its purest form. Patients that suffer form MS pains and spasms can get some relief from this substance. In Italy, many neurologists are using this substance and both patients as neurologist are […]

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Endometriosis, menstruation pains and treatment with palmitoylethanolamide

Seven out of 10 menstruating women suffer from abdominal and menstruation pain. The medical term for abdominal pain during menstruation is dysmenorrhea. The so-called primary abdominal pain arises due to the ovulation, which is called primary dysmenorrhea. One of the most common causes of secondary dysmenorrhea is endometriosis. Over 1 out of 10 women suffers […]

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Study supports the significance of palmitoylethanolamide for endometriosis pain

A new study among 24 women with severe menstrual pains due to endometriosis and pain during intercourse, supports the use of palmitoylethanolamide (PEA as in PeaPure). The women experienced a clear decrease in pain, were able to take less pain medicine and experienced less pain during intercourse. The recommended dose is 400mg three times a […]

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Natural treatment of Parkinson with body’s own palmitoylethanolamide

The role of palmitoylethanolamide in Parkinson.

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The Truth about PEA (palmitoylethanolamide) in recent formulations

Palmitoylethanolamide, only formulations containing PEA-m, PEA-um and PEA-opt are clinically tested on safety and efficacy.

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Low-grade inflammation in Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS); treatment by palmitoylethanolamide supplement

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a disorder difficult to understand for many, especially for doctors who too often think this disorder does not exist. Well it does! Modern neurobiological research clearly found new insights in the cause of this disease. New findings point out that inflammatory pathways and immunity derangements play an important role in the pathophysiology of Myalgic Encephalomyelitis […]

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Chronic prostatitis/chronic pelvic pain syndrome, neurologic inflammation and autoimmune disease and palmitoylethanolamide

In a recent review it was highlighted that symptoms of chronic prostatitis/CPPS appear to cluster into a group with primarily pelvic or localized disease,  as well as in a group with more systemic symptoms, such as generalized pain disorders. There seems to exist a cluster of chronic pain conditions related to chronic inflammation, and in this cluster we can […]

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Visceral pain: a forgotten topic

Prof. Fernando Cervero from Montreal, Canada discussed at the EFIC 2013 in Florence an underserved but very important topic: visceral pain. Visceral pain is very underserved, as patients visit often organ specialists not interested in pain itself, but directly focussing on the underlying illness. However, as visceral pain is a cinderella in the pain field, […]

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Visceral pain: basic mechanism and science

At the 2013 EFIC congress on pain in FLorence the Ulf Lindblom Special Lecture was dedicated to visceral pain, and presented by Prof. dr. F. Cervero from The Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada. Cervero pointed out that visceral pain is a prominent symptom of many clinical conditions. Visceral […]

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Palmitoylethanolamide, PEA: key items presented

In the following sequence of presentations we bring to you the essence of knowledge around the body-own compound and supplement palmitoylethanolamide! We start with the general introduction, an overview of palmitoylethanolamide, an endogenous cellular protectant in plants, invertebrates, vertebrates and humans, tested extensively since 1970 and widely available as food supplement. Its main action is […]

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Neuropathic pain: microglia controls neuronal network excitability

Microglia-neuron interactions are leading to altered neural network excitability, the pathogenetic base of neuropathic pain. Modern research demonstrates that one of the key factors driving neurons nuts in neuropathic pain is the inflammatory compound ‘Brain-derived neurotrophic factor (BDNF)’, released by microglia. [1] Microglial BDNF plays a key role in controlling neuronal excitability by causing disinhibition. This […]

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Painful legs and moving toes syndrome

Painful legs and moving toes syndrome, it really exist. And it is how it sounds. The legs start burning and aching, and the toes start moving on themselves. It is very uncommon, but it can be found. Neurologists found 14 cases of painful legs and moving toes (PLMT) syndrome out of 4,780 patients with movement disorders diagnosed at Mayo Clinic. So all these patients already suffered from one issue, a movement disorder, like Parkinson’s disease or dystonia.

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Clinical trial methodology in neuropathic pain

The EMEA published a guideline on how to conduct studies in neuropathic pain, in 2007. It is worth while quoting from this guideline:

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Trigeminus neuralgia treated with Gamma Knife surgery

Trigeminus neuralgia is difficult to treat. For those patients were medication such as carbamazepin is not helpful, the neurosurgeon can treat with the so called Gamma Knife…. 

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CNSB015 at Third International Congress on Neuropathic Pain in Athens, Greece

Relevare Pharmaceuticals Ltd. presented results for CNSB015 (flupirtine), at the Third International Congress on Neuropathic Pain on May 27 -30 in Athens, Greece, which we visited. Flupirtine belongs to the class of aminopyridines, like fampyridine used in MS, and is a centrally acting nonopioid analgesic. It is on the market in Europe since 1984 under the names Katadolon and Trancolong. It is a non-opioid, non-NSAID, non-steroidal analgesic. Flupirtine therefore is an already established clinical analgesic for musculoskeletal pain. 

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Neuropathy and male anorgasmia, penile neuropathy

In our clinic we see patients suffering from neuropathy only. Inability to have an erection is a common finding, for instance in diabetes. Inability to experience an orgasm, while semen flows however, is rare.

Recently in my clinics I saw two male patients suffering from neuropathy, one due to diabetes and onther due to chemotherapy, both have the same issue: they ejaculate, but without any orgasmic feeling. They describe it like a candle going out instead of fireworks. This prompted me to write this entry on penile neuropathy.

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Palmitoylethanolamide: for the treatment of cannabis dependence.

Drs M. Coppola and R. Mondola from the Department of Addiction, in Alba, Italy and the Department of Mental Health, Saluzzo, Italy published an interesting paper on the putative use of palmitoylethanolamide (PEA) in the treatment of Cannabis dependency. They bring forward this hypothesis based on a variety of findings,

They point out that like cannabis, evidences suggest that PEA, as THC, has anti-inflammatory and anti-nociceptive activity in humans as well as in animal models. PEA, an anandamide congener, might have PEA has anti-craving effects in cannabis dependent patients, is efficacious in the treatment of withdrawal symptoms, produces a reduction of cannabis consumption and is effective in the prevention of cannabis induced neurotoxicity and neuro-psychiatric disorders due to its pleotropic mechanism of action.

Source: Coppola M, Mondola R. Palmitoylethanolamide: From endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. Med Hypotheses. 2013 Jul 26. doi:pii: S0306-9877(13)00338-1.

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Wise reactions of glia in neuropathic pain possible

Gia cells play an important role in neuropathic pain. So important that some scientists prefer to speak about gliopathic pain in stead of neuropathic pain. These cells produce their own modulators we could even say, their own endogeneous ‘painkillers’. These modulators play an important role in decreasing winding up mechanisms in neuropathic pain. Anandamide (arachidonoylethanolamide, AEA) and its sistermolecule palmitoylethanolamide (PEA, Normast), both are such modulators, and these molecules have positive influences  in neuropathic pain and inflammation related to neuropathic pain. Both molecules are classical autocoids, and they fulfill the three criteria required for autocoids of lipid transmitters:

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Chronic pain due to neuropathy and sciatica treated with PEA

sciatic-pain-normast.jpg Chronic pain due to neuropathy and sciatica treated with PEA. Severe neuropathic pain due to and a chronic neuropathy as well as due to nerve compression by a herniated disk, both pains reacted quick and after administering PEA the patient’s pain decreased considerably, and he could start working again, after being on sick leave for a long period of time. Since 2012 PEA is available as PeaPure, capsules containing only palmitoylethanolamide, without any chemical excipients. 

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The mastcell in neuro-inflammation, pain and modulation by palmitoylethanolamide

Since 1993, after the work of the Nobel price laureate Rita Levi-Montalcini on palmitoylethanolamide and its inhibiting effects on inflammation, much happened. It seems that all Montalcini said in 1993 about inflammation, the role of the mastcell and the modulation of the mastcell by the endogenous modulator palmitoylethanolamide has been substantiated by new research.

Recently, a number of pharmacologists reviewed the literature and found new experimental data supporting the role of the mastcell in our central nervous system. They state that their experimental data strongly suggest the participation of mastcells in the processes which eventually lead to autoimmune demyelination, a kind of neuroinflammation, which is of relevance for e.g. multiple sclerosis.

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Diabetic Neuropathy: introduction

Diabetes and neuropathy: a simple explanation by Jan M. Keppel Hesselink, MD, PhD, professor of molecular pharmacology and director R&D of the clinic for treatment of neuropathic pain in Soest, the Netherlands. Jan Keppel Hesselink is also initiator of the professional LinkedIn group for neuropathic pain and neuropathy.

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