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In this section English articles are published on neuropathy.

Phenytoin cream normalizes neural overactivity in skin in neurogenic inflammation

Phenytoin cream is a newly developed cream by the Institute of Neuropathic Pain and protected by 2 patents, filed on December 6th, 2016. The cream contains 5 or 10% phenytoin and here we picture one of the mechanisms of action, via the keratinocyte.

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MicroPEA: an essential component of modern PEA formulations!

MicroPEA is the content of special patented PEA formulations. Only these formulations have a long trackrecord of safety and efficacy.

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Polyneuropathy: an Introduction

Polyneuropathy: all you want to know

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Rheumatism, Bechterew disease, mast cells and palmitoylethanolamide

Bechterew is a rheumatic disorder based on chronic inflammation. Since some years the treatment with the natural painkiller and anti-inflammation compound palmitoylethnanolamide in its new formulations containing micro-PEA gives new hope.

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Prostate, chronic pain and treatment with palmitoylethanolamide

Prostate Pains can be treated with the natural anti-inflammatory compound palmitoylethanolamide (PEA). We prefer PEA formulations containing micro-PEA (m-PEA, um-PEA and PEA-opt) as in Normast, PeaPure and PeaPlex.

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Treat burning and painful vagina with natural substance PEA

Vaginal pain, vaginal burning! This is quite common, more so than we think. Specifically among women older than 45 years of age. Many women don’t speak about it, but they do suffer from it. In case of vaginal pain, pain during intercourse or vaginal burning, it is obvious that the doctor or gynecologist needs to […]

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Amputation pain, phantom limb pain and treatment with palmitoylethanolamide

Post-amputation pain is a serious and difficult to treat pain, also referred to as phantom pain. Phantom pain can occur in the arms, legs, hand and feet after amputation, but also in cases of breast amputation related to cancer. Palmitoylethanolamide (PEA) is a natural and body’s own substance that has a pain relieving and anti-inflammatory […]

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MS spasms and pain treatment with body’s own substance palmitoylethanolamide

Palmitoylethanolamide is a new and promising treatment against pain and inflammation. It’s available as a supplement without prescription. PeaPure is a supplement in its purest form. Patients that suffer form MS pains and spasms can get some relief from this substance. In Italy, many neurologists are using this substance and both patients as neurologist are […]

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Endometriosis, menstruation pains and treatment with palmitoylethanolamide

Seven out of 10 menstruating women suffer from abdominal and menstruation pain. The medical term for abdominal pain during menstruation is dysmenorrhea. The so-called primary abdominal pain arises due to the ovulation, which is called primary dysmenorrhea. One of the most common causes of secondary dysmenorrhea is endometriosis. Over 1 out of 10 women suffers […]

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Study supports the significance of palmitoylethanolamide for endometriosis pain

A new study among 24 women with severe menstrual pains due to endometriosis and pain during intercourse, supports the use of palmitoylethanolamide (PEA as in PeaPure). The women experienced a clear decrease in pain, were able to take less pain medicine and experienced less pain during intercourse. The recommended dose is 400mg three times a […]

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Natural treatment of Parkinson with body’s own palmitoylethanolamide

The role of palmitoylethanolamide in Parkinson.

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The Truth about PEA (palmitoylethanolamide) in recent formulations

Palmitoylethanolamide, only formulations containing PEA-m, PEA-um and PEA-opt are clinically tested on safety and efficacy.

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Low-grade inflammation in Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS); treatment by palmitoylethanolamide supplement

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a disorder difficult to understand for many, especially for doctors who too often think this disorder does not exist. Well it does! Modern neurobiological research clearly found new insights in the cause of this disease. New findings point out that inflammatory pathways and immunity derangements play an important role in the pathophysiology of Myalgic Encephalomyelitis […]

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Chronic prostatitis/chronic pelvic pain syndrome, neurologic inflammation and autoimmune disease and palmitoylethanolamide

In a recent review it was highlighted that symptoms of chronic prostatitis/CPPS appear to cluster into a group with primarily pelvic or localized disease,  as well as in a group with more systemic symptoms, such as generalized pain disorders. There seems to exist a cluster of chronic pain conditions related to chronic inflammation, and in this cluster we can […]

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Visceral pain: a forgotten topic

Prof. Fernando Cervero from Montreal, Canada discussed at the EFIC 2013 in Florence an underserved but very important topic: visceral pain. Visceral pain is very underserved, as patients visit often organ specialists not interested in pain itself, but directly focussing on the underlying illness. However, as visceral pain is a cinderella in the pain field, […]

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Visceral pain: basic mechanism and science

At the 2013 EFIC congress on pain in FLorence the Ulf Lindblom Special Lecture was dedicated to visceral pain, and presented by Prof. dr. F. Cervero from The Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada. Cervero pointed out that visceral pain is a prominent symptom of many clinical conditions. Visceral […]

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Palmitoylethanolamide, PEA: key items presented

In the following sequence of presentations we bring to you the essence of knowledge around the body-own compound and supplement palmitoylethanolamide! We start with the general introduction, an overview of palmitoylethanolamide, an endogenous cellular protectant in plants, invertebrates, vertebrates and humans, tested extensively since 1970 and widely available as food supplement. Its main action is […]

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Neuropathic pain: microglia controls neuronal network excitability

Microglia-neuron interactions are leading to altered neural network excitability, the pathogenetic base of neuropathic pain. Modern research demonstrates that one of the key factors driving neurons nuts in neuropathic pain is the inflammatory compound ‘Brain-derived neurotrophic factor (BDNF)’, released by microglia. [1] Microglial BDNF plays a key role in controlling neuronal excitability by causing disinhibition. This […]

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Pharmacotherapy of painful neuropathy

In the journal JAMA, October 2009, was a description of a patient with diabetes mellitus and much discomfort from neuropathy. The doctor described the case, showed a list of drugs to see the usefulness of these values. Here on this table we see a number of recent rfindings and the relative strength of various painkillers for neuropathic pain. In this paper a clear message: Lyrica and Cymbalta are no better than older and cheaper drugs, which may be even better!

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Neuropathic pain: NICE clinical guideline DRAFT (October 2009)

End of 2009 the Neuropathic pain NICE clinical guideline DRAFT became available. (October 2009). Here some highlights of this guideline. Nice stands for National Institute for Health and Clinical Excellence. 

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Amitriptyline as good as pregabalin for painful diabetic Neuropathy

Amitriptyline as good as pregabalin for painful diabetic neuropathy says a review ariticle on Diabetes in control.com, dated March 23, 2010. This is based on the results of a head to head comparison of both drugs in a group of 41 patients. The study had some methodological flaws, but the results are in line with our expectations and experiences. Both drugs have similar efficacy, but amitriptyline, if dosed higher up (>25 mg an) has more side- effects.

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Pudendal neuropathy: treatment with amitriptyline cream

pudendusneuropathie.jpg A patient suffering from pudendal neuropathy or neuralgia, or perineodynia, with high pain scores reacting positive on our in house developed 5% amitrptyline cream, pain severity decreased more than 50% after starting this cream. The pudendal nerve carries senations from the external genitals, the lower rectum, and the perineum (between the genitals and the anus).

Neuropathy is in general  disease of the peripheral nerves, so pudendal neuropathy can cause symptoms in any of these areas. Some people have mostly rectal pain, sometimes with defecation problems. Others have mostly pain in the perineum or genitals. The symptoms may include stabbing, twisting or burning pain, pins and needles, numbness or hypersensitivity, all classical neuropathic symptoms. Usually the symptoms are made worse by sitting, as in this patient.

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Neuropathic pain, glia and cannabis

Despite the frequency of diabetes mellitus and its relationship to diabetic peripheral neuropathy (DPN) and neuropathic pain (NeP), our understanding of underlying mechanisms leading to chronic pain in diabetes remains poor. Recent evidence has demonstated a prominent role of microglial cells in neuropathic pain states. One potential therapeutic option gaining clinical acceptance is the cannabinoids, for which cannabinoid receptors (CB) are expressed on neurons and microglia. These are the opening words of a brand new article on ‘Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain’ from the hand of Cory C Toth and colleagues. 

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Obesity, chronic low grade inflammation, pain and low dose naltrexone

Obesity-associated health complications are thought to be in part due to the low-grade proinflammatory state that characterizes this disease. A quote from a recent article on obesity. In our clinic we regulary see obese diabetic patients, suffering from chronoc pain. Sometimes this pain resembles neuropathic pain, sometimes it is more of a fibrobyalgia sort. We gained some experience in treating chronic pain by using low dose naltrexone, sometimes together with low dose tramadol and would like to share this experience.

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Opioids activate Glia: counterproductive in neuropathic pain…

Opioids can cause chronic pain, especially neuropathic pain, were glia and asterocytes are happy to become over activated.  After chronic opiate exposure, this excitatory effect emerges contributing to analgesic tolerance and opioid-induced hyperalgesia, and the glia are key in this negative pain cascade.

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Severe Lyrica® refractory sciatic pain treated with palmitoylethanolamide

normast-sciatic-pain.jpg A medical doctor, former president of a big dutch hospital, suffered from severe neuropathic sciatic pain, painscore 10 over 10, without any response on pregabaline, only severe side effects, treated with palmitoylethanolamide, a body own fatty acid with analgesic properties.

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Normast and PeaPure: questions and answers

What exactly is Normast  and PeaPure?

In this page many clinical and patient driven questions will be discussed. This page is under construction. A website has been created for palmitoylethanolamide related science only.

Normast and PeaPure are brandnames for supplements containing a body own molecule, palmitoylethanolamide, against pain and inflammation.  

Normast however contains magnesium stearate, a alien fat for our body, undigestable and an excipient doctors recommend to avoid.

All scientific information is discussed in this review.

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Palmitoylethanolamide: a natural protector against lipid peroxidation

N-Acylethanolamines (NAEs) (fatty acid ethanolamides) are naturally occurring hydrophobic molecules usually present in a very small amount in many mammalian tissues and cells [1] and [2]. Moreover, NAEs are normally present in biological fluids, such as blood [2], in very low concentrations. The physiological levels of important NAEs in mammalian blood plasma are in the range 2.8–5.2 pmol/ml for anandamide (AEA); 9.4–16.7 pmol/ml for PEA; 8.1–10.3 pmol/ml for oleylethanolamide (OEA) [2], [3] and [4]. However, the NAEs levels in blood plasma could be modified in pathological conditions, e.g., the physiological concentrations of AEA in human plasma are 4 pmol/ml, but these concentrations are increased up to 18–30 pmol/ml in sera of patients with endotoxic shocks [5]. In vivo studies demonstrated that NAEs could accumulate in injured tissues, such as, e.g., in myocardium infarcted areas [6], and in post decapitative brain ischemia [7].

And 

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Extended release oxymorphone may help treating chronic neuropathic pain

Extended release oxymorphone may help treating chronic neuropathic pain due to a small pilot trial published during a congress.

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Bupropion for the treatment of neuropathic pain.

Bupropion for the treatment of neuropathic pain. A short review.

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